AI (artificial intelligence)-brain interface requires conformal attachment of electronic devices on the brain surface and wireless power delivery between power sources and brain-implantable devices. In this regard, our group has developed flexible biomedical optoelectronics (i.e. micro light-emitting diodes), brain-implantable electrodes, flexible drug delivery systems and flexible wireless power delivery systems.
Flexible biomedical optoelectonic systems are very useful since they can be conformally placed on a heart and a brain, and can be rolled upon blood vessels of the spine to diagnose or treat various diseases. Light-emitting diodes (LEDs) have been actively studied as therapeutic and diagnostic tools for medical treatment. Our flexible inorganic LEDs based on GaAs or GaN enable implantable, flexible biomedical optoelectronic devices. Flexible inorganic biomedical optoelectronic system could be utilized in the human body for biomedical sensing of disease and even control of neural optogenetic signals simultaneously. We have developed high performance flexible vertical ILEDs (f-VLEDs) using anisotropic conductive films, for extremely efficient and highly aligned f-LED arrays.
We have developed a unique flexible electrocorticogram (ECoG) system, called iWEBS (insertable wrapping electrode array beneath the skull), for spatiotemporal mapping of neural interactions. Our invivo flexible electrodes can be inserted through a small cranial slit and wrap onto the cortical brain surface in living animals. This technology facilitates not only minimizing brain damage but also keeping the stable intact of flexible electrodes, which is essential for measuring functional connectivity across the wide-range cortical areas. Using our flexible iWEBS, we could record dynamic changes of optogenetic signals across major cortical brain domains of freely moving mice. Our flexible iWEBS represents a significant improvement over conventional ECoG recording, therefore, is a competitive recording system for mapping wide-range brain connectivity under various behavioral conditions.
Drug delivery systems play a crucial role in the treatment and management of serious medical conditions. Microelectromechanical systems (MEMS) technologies have allowed the development of advanced miniaturized devices for medical and biological applications. However, flexible drug delivery systems (f-DDS) is difficult to achieve due to a brittle nature of devices. Our group has developed a flexible drug delivery microdevice (f-DDM) with controlled release based on innovative MEMS technology and inorganic lase lift-off (ILLO) technique. The f-DDM was conformally implanted on the cerebral cortex of live mice, and electrically triggered drug delivery to local tissue was successfully demonstrated. This technology can be integrated with micro-valves, micro-sensors, and CMOS IC-based microcontroller chip to achieve feedback control at a specific time, dosage, and location on curved surface inside human body.
Flexible wireless power delivery system has become essential part of future flexible, IoT, wearable and implantable biomedical devices for realization of AI-brain interface. In Witricity power technology, energy can be efficiently delivered using strong resonant inductive coupling based on oscillating magnetic fields. The power transfer system, which consists of transmitters and receivers with magnetic loop antennas critically tuned to the same frequency, provides the energy to the battery-free biomedical devices. Our group has developed flexible wireless power delivery system for implantable and portable biomedical devices, including the flexible drug delivery system and brain optical stimulator with flexible vertical LED, with improved reliability and feasibility of the system.
[Related References]
“Optogenetic Mapping of Functional Connectivity in Freely Moving Mice via iWEBS”, ACS Nano, 10, 2791, 2016
“Optogenetic Control of Body Movements via Flexible Vertical Light-Emitting Diodes on Brain Surface”, Nano Energy, 44, 447, 2018
“Flexible Wireless Powered Drug Delivery System for Targeted Administration on Cerebral Cortex”, Nano Energy, 51, 102, 2018
“Flexible Wireless Powered Drug Delivery System for Targeted Administration on Cerebral Cortex”, Nano Energy, 51, 102, 2018
“Monolithic Flexible Vertical GaN Light-Emitting Diodes for Transparent Wireless Brain Optical Stimulator”, Adv. Mater., 30, 1800649, 2018
AI (artificial intelligence)-brain interface requires conformal attachment of electronic devices on the brain surface and wireless power delivery between power sources and brain-implantable devices. In this regard, our group has developed flexible biomedical optoelectronics (i.e. micro light-emitting diodes), brain-implantable electrodes, flexible drug delivery systems and flexible wireless power delivery systems.
Flexible biomedical optoelectonic systems are very useful since they can be conformally placed on a heart and a brain, and can be rolled upon blood vessels of the spine to diagnose or treat various diseases. Light-emitting diodes (LEDs) have been actively studied as therapeutic and diagnostic tools for medical treatment. Our flexible inorganic LEDs based on GaAs or GaN enable implantable, flexible biomedical optoelectronic devices. Flexible inorganic biomedical optoelectronic system could be utilized in the human body for biomedical sensing of disease and even control of neural optogenetic signals simultaneously. We have developed high performance flexible vertical ILEDs (f-VLEDs) using anisotropic conductive films, for extremely efficient and highly aligned f-LED arrays.
We have developed a unique flexible electrocorticogram (ECoG) system, called iWEBS (insertable wrapping electrode array beneath the skull), for spatiotemporal mapping of neural interactions. Our invivo flexible electrodes can be inserted through a small cranial slit and wrap onto the cortical brain surface in living animals. This technology facilitates not only minimizing brain damage but also keeping the stable intact of flexible electrodes, which is essential for measuring functional connectivity across the wide-range cortical areas. Using our flexible iWEBS, we could record dynamic changes of optogenetic signals across major cortical brain domains of freely moving mice. Our flexible iWEBS represents a significant improvement over conventional ECoG recording, therefore, is a competitive recording system for mapping wide-range brain connectivity under various behavioral conditions.
Drug delivery systems play a crucial role in the treatment and management of serious medical conditions. Microelectromechanical systems (MEMS) technologies have allowed the development of advanced miniaturized devices for medical and biological applications. However, flexible drug delivery systems (f-DDS) is difficult to achieve due to a brittle nature of devices. Our group has developed a flexible drug delivery microdevice (f-DDM) with controlled release based on innovative MEMS technology and inorganic lase lift-off (ILLO) technique. The f-DDM was conformally implanted on the cerebral cortex of live mice, and electrically triggered drug delivery to local tissue was successfully demonstrated. This technology can be integrated with micro-valves, micro-sensors, and CMOS IC-based microcontroller chip to achieve feedback control at a specific time, dosage, and location on curved surface inside human body.
Flexible wireless power delivery system has become essential part of future flexible, IoT, wearable and implantable biomedical devices for realization of AI-brain interface. In Witricity power technology, energy can be efficiently delivered using strong resonant inductive coupling based on oscillating magnetic fields. The power transfer system, which consists of transmitters and receivers with magnetic loop antennas critically tuned to the same frequency, provides the energy to the battery-free biomedical devices. Our group has developed flexible wireless power delivery system for implantable and portable biomedical devices, including the flexible drug delivery system and brain optical stimulator with flexible vertical LED, with improved reliability and feasibility of the system.
[Related References]
“Optogenetic Mapping of Functional Connectivity in Freely Moving Mice via iWEBS”, ACS Nano, 10, 2791, 2016
“Optogenetic Control of Body Movements via Flexible Vertical Light-Emitting Diodes on Brain Surface”, Nano Energy, 44, 447, 2018
“Flexible Wireless Powered Drug Delivery System for Targeted Administration on Cerebral Cortex”, Nano Energy, 51, 102, 2018
“Flexible Wireless Powered Drug Delivery System for Targeted Administration on Cerebral Cortex”, Nano Energy, 51, 102, 2018
“Monolithic Flexible Vertical GaN Light-Emitting Diodes for Transparent Wireless Brain Optical Stimulator”, Adv. Mater., 30, 1800649, 2018